Dfam is growing up. This is the first major expansion of the database since it’s inception. We’ve added repeat families from four new organisms: mouse, zebrafish, fruit fly, and nematode. In total, this release includes 2,844 new familes ( 4,150 total ).
Alex Nord has just been awarded a Center for Biomolecular Structure and Dynamics Graduate Student Fellowship for the summer of 2016. The fellowship will support Alex while he continues research on using spaced seeds to boost both speed and sensitivity in the context of database search with profile hidden Markov models (in HMMER, of course).
Read more at: http://news.umt.edu/2015/06/060915cbsd.php
RNAcentral is an open resource that provides a unified platform for accessing non-coding RNA sequences from a broad range of ncRNA databases. Anton Petrov has just announced a 3rd release. Along with a slew of new features, RNAcentral is now powered by our nhmmer which they’ve found to be more sensitive than Exonerate. They’re using the recently-released HMMER3.1b2, a stable beta release that implements our new accelerated DNA search based on seed finding with the FM index data structure (I’ll describe that here once we get the paper submitted … soon). Exciting days.
New paper describing recent advances in the HMMER web server (primarily driven by the endlessly talented Rob Finn and Jody Clements):
Finn RD, Clements J, Arndt W, et al. (2015) HMMER web server: 2015 update. Nucleic Acids Res. DOI: 10.1093/nar/gkv397
Also, a little love from the EMBL-EBI press machine: A powerful HMMER for data mining. (The last line reads like a call to arms: “The next step for the collaborators is to extend the software to accommodate DNA searches, which involves far larger datasets.”)
With Dfam, we are striving to build models of repeat families that yield high sensitivity without undue false annotation. In this release of Dfam, we have improved our model building strategy to reduce the potential for false annotation, especially in the context of overextending alignments around true interspersed repeat instances.
Go to the Xfam blog to read the rest … (Say hello to Dfam1.4.)
Outstanding senior and soon-to-be UM Computer Science graduate student Rutger Evans is heading to England. He’ll spend almost three months this summer performing research at the European Bioinformatics Institute (EMBL-EBI), located a few miles down the road from Cambridge, UK.